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KMID : 0605820110180020182
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Korean Journal of Pediatric Infectious Diseases
2011 Volume.18 No. 2 p.182 ~ p.192
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The Influence of Atopic Findings on Severity of Pneumonia in Children with 2009 Pandemic Influenza A (H1N1) Infection
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Kim Jong-Hee
Kim Hyun-Jeung
Kang Im-Ju
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Abstract
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Purpose: Atopic findings may be associated with severity of pneumonia in 2009 pandemic influenza A (H1N1) infection, which could suggest a possible association between atopic findings and the severity of viral infections. Thus, we studied association between atopic findings and severity of disease in children with H1N1 influenza infection.
Methods: A retrospective study was performed in 74 children admitted in a single tertiary institute and confirmed as H1N1 patients by reverse transcriptase (RT) - polymerase chain reaction (PCR). They were divided into 2 groups according to the severity of pneumonia. We evaluated whether the atopic finding is risk factor between the two groups.
Results: Children with severe pneumonia had higher percentages of serum eosinophilia (88% vs 40%, P <0.001), asthma (65% vs 35%, P =0.011), allergic rhinitis (71% vs 40%, P =0.009), and IgE level (P =0.007). We found positive correlations between aeroallergen sensitizations and severity of pneumonia (82% vs 53%, P =0.007).
Conclusion:Among patients with H1N1 pneumonia, asthma and atopic findings are risk factors for severity of pneumonia.
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KEYWORD
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2009 Pandemic influenza A (H1N1), Pneumonia, Atopy, Allergic disease
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